BursteinDGrayMHartmanADiffusion of small solutes in cartilage as measured by nuclear magnetic resonance (NMR) spectroscopy and imagingJ Othopaedic Res199311465–47810.1002/jor.1100110402
2.
Fernandez-CanonJMGranadinoBBeltran-Valero de BernabeDThe molecular basis of alkaptonuriaNat Genet19961419–2410.1038/ng0996-19
3.
GelseKEkiciABCipaFMolecular differentiation between osteophytic and articular cartilage—clues for transient and permanent chondrocyte phenotypeOsteoarthritis Cartil201220162–17110.1016/j.joca.2011.12.004
4.
HuberMTrattnigSLintnerFAnatomy, biochemistry, and physiology of articular cartilageInvestig Radiol200035573–58010.1097/00004424-200010000-00003
5.
KellerJMMacaulayWNew developments in ochronosis: review of the literatureRheumatol Int20042581–8510.1007/s00296-004-0498-1
6.
La DuBNZannoniVGLasterLThe nature of the defect in tyrosine metabolism in alcaptonuriaJ Biol Chem1958230251–260
7.
LaschiMTintiLBraconiDHomogentisate 1,2 dioxygenase is expressed in human osteoarticular cells: implications in alkaptonuriaJ Cell Physiol201222793254–3257342788310.1002/jcp.24018
8.
MannoniASelviELorenziniSAlkatonuria, ochronosis, and ochronotic arthropathySemin Arthritis Rheum200433239–24810.1053/S0049-0172(03)00080-5
PhornphutkulCIntroneWJPerryMBNatural history of alkatonuriaN Engl J Med20023472111–212110.1056/NEJMoa021736
11.
RoezilliPDethmersDRoseDMovement of interstitial water through loaded articular cartilageJ Biomechanics198316169–17910.1016/0021-9290(83)90124-0
12.
Ross MH, Pawlina W. “Cartilage.” Histology: A Text and Atlas: With Correlated Cell and Molecular Biology. Baltimore, MD: Lippincott Williams & Wilkins, 2006. 182–201.
13.
SpreaficoAMillucciLGhezziLAntioxidants inhibit SAA formation and pro-inflammatory cytokine release in a human cell model of alkaptonuriaRheumatology (Oxford, England)20135291667–167310.1093/rheumatology/ket185
14.
TaylorAMBoydeAWilsonPJMThe role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuriaArthritis Rheum201163123887–389610.1002/art.30606
15.
TaylorAMPrestonAJPaulkNKOchronosis in a murine model of alkaptonuria is synonymous to that in a human conditionOsteoarthritis Cartil201220880–88610.1016/j.joca.2012.04.013
16.
TaylorAMWlodarskiBPriorIAUltrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigmentRheumatology (Oxford)2010491412–141410.1093/rheumatology/keq027
17.
TintiLTaylorAMSantucciADevelopment of an in vitro model to investigate joint ochronosis in alkaptonuriaRheumatology (Oxford)2011502271–27710.1093/rheumatology/keq246
18.
YamadaTYamamotoTShidaJSubchondral insufficiency fracture of the femoral head in a patient with alkaptonuriaSkeletal Radiol201443827–83010.1007/s00256-013-1796-z
19.
ZannoniVGLomtevasNGoldfingerSOxidation of homogentisic acid to ochronotic pigment in connective tissueBiochim Biophys Acta1969177194–10510.1016/0304-4165(69)90068-3