Abstract
Background:
Granular parakeratosis is a hyperkeratotic eruption of unknown etiology that occurs in the axilla and other intertriginous areas. The histologic features are unique for the retention of keratohyalin granules in the stratum corneum.
Objective:
The aim of the article is to review the clinical manifestations and treatment of granular parakeratosis.
Methods:
A case report and literature review are presented.
Results:
Twenty-six cases of granular parakeratosis now have been reported and reviewed.
Conclusion:
Granular parakeratosis occurs predominantly in middle age women and most frequently in the axilla. A number of treatments have been applied to the 26 cases reported to date, without consistent responses. No evidence-based therapy can be suggested at present.
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