It is well known that congenital or infantile fibrosarcoma has a much less aggressive behavior than fibrosarcoma in adults, and it rarely metastasizes. We report a case of congenital fibrosarcoma in a 26-wk-old fetus, the diagnosis of which was made by an in utero needle core biopsy. Metastatic tumors were identified at autopsy when the pregnancy was terminated 3 wk later. English literature of metastatic congenital fibrosarcoma was also reviewed.
StoutAP. Fibrosarcoma in infants and children. Cancer1962;15:1028–1040.
2.
KempsonRL, FletcherCD, EvansHL, Atlas of Tumor Pathology, Third Series Fascicle 30, Tumors of the Soft Tissues. Washington, DC: Armed Forces Institute of Pathology, 2001:95–99.
3.
HaywardPG, OrgillDP, MullikenJB, Congenital fibrosarcoma masquerading as lymphatic malformation: report of two cases. J Pediatr Surg1995;30:84–88.
4.
SouleEH, PritchardDJ. Fibrosarcoma in infants and children: a review of 110 cases. Cancer1977;40:1711–1721.
5.
BourgeoisJM, KnezevichSR, MathersJA, Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol2000;24:937–946.
6.
FavaraB, HuffD, JaffeR, , ed. A Model Prenatal Autopsy Protocol. Washington, DC: Armed Forces Institute of Pathology, 1994:53–54.
7.
WeissSW, GoldblumJR. Enzinger and Weiss's Soft Tissue Tumors, 4th ed. St. Louis: Mosby, 2001:377–383.
8.
CoffinCM, JaszczW, O'SheaPA, So-called congenital-infantile fibrosarcoma: does it exist and what is it. Pediatr Pathol1994;14:133–150.
RootmanJ, CarvounisEP, DolmanCL, Congenital fibrosarcoma metastatic to the choroid. Am J Ophthalmol1979;87:632–638.
12.
LundgrenL, AngervallL, StenmanG, Infantile rhabdomyosarcoma. A high-grade sarcoma distinguishable from infantile fibrosarcoma and rhabdomyosarcoma. Hum Pathol1993;24:785–795.
13.
KnezevichSR, GarnettMJ, PysherTJ, ETV6-NTRK3 gene fusion and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res1998;58:5046–5048.
14.
ShengWQ, HisaokaM, OkamotoS, Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues. Am J Clin Pathol2001; 115:348–355.
