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Research article

First published 2018-12

Multiple daytime administration of the selective orexin-2 receptor antagonist JNJ-42847922 induces somnolence in healthy subjects without residual central effects

Peter D van der Ark, Georg Golor, Luc van Nueten [...]

Journal of Psychopharmacology

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Research article

First published 2019-2

The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind,placebo controlled,crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia

Sander Brooks, Gabriël E Jacobs, Peter de Boer [...]

Journal of Psychopharmacology

Open access

Research article

First published 2018-3

Orexin-A protects SH-SY5Y cells against H 2 O 2 -induced oxidative damage via the PI3K/MEK 1/2 /ERK 1/2 signaling pathway

Chun-Mei Wang, Chun-Qing Yang, Bao-Hua Cheng [...]

International Journal of Immunopathology and Pharmacology

Open access

Research article

First published 2024-9

A male-specific mechanism of meningeal nociceptor sensitization promoting migraine headache

Caroline M. Kopruszinski, Grace Lee, Laurent K. Martin [...]

Cephalalgia

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Research article

First published 2018-6

A randomized Phase 2 study to evaluate the orexin-2 receptor antagonist seltorexant in individuals with insomnia without psychiatric comorbidity

Peter De Boer, Wayne C Drevets, Hany Rofael [...]

Journal of Psychopharmacology

Open access

Review article

First published 2017

A review of orexin’s unprecedented potential as a novel,highly-specific treatment for various localized and metastatic cancers

Nicole L Graybill, Volkmar Weissig

Sage Open Medicine

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Research article

First published 2017-04

Orexin-A Protects Human Neuroblastoma SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity: Involvement of PKC and PI3K Signaling Pathways

Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, Mehdi Abbasnejad

Rejuvenation Research

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Research article

First published 2012-07

Controlled Cortical Impact Traumatic Brain Injury Acutely Disrupts Wakefulness and Extracellular Orexin Dynamics as Determined by Intracerebral Microdialysis in Mice

Jon T. Willie, Miranda M. Lim, Rachel E. Bennett [...]

Journal of Neurotrauma

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Other

First published 2011-8

Orexin Genes Polymorphisms and Obstructive Sleep Apnea Syndrome

Wael A. Ahmed, Toshiyuki Fujisawa, Yoichi Nishimura

Otolaryngology–Head and Neck Surgery

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Research article

First published 2009-07

The effect of clomipramine on wake/sleep and orexinergic expression in rats

P Feng, Y Hu, D Li [...]

Journal of Psychopharmacology

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