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Research article

First published 2026-4

Investigating the Biophysical Properties and In Vivo Activity of 7′,5′-Alpha-Bicyclo-DNA Phosphodiester Backbone Gapmer Antisense Oligonucleotides

Damien Evequoz, Remya R. Nair, Martina Cadeddu [...]

Nucleic Acid Therapeutics

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Research article

First published 2018-10

Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides

Takeshi Kasuya, Akira Kugimiya

Nucleic Acid Therapeutics

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Research article

First published 2019-2

RNA Reduction and Hepatotoxic Potential Caused by Non-Gapmer Antisense Oligonucleotides

Shin-Ichiro Hori, Yasunori Mitsuoka, Akira Kugimiya

Nucleic Acid Therapeutics

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Research article

First published 2012-10

Chemical Modification Study of Antisense Gapmers

Robert Stanton, Simone Sciabola, Christopher Salatto [...]

Nucleic Acid Therapeutics

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Research article

First published 2007-09

Fine-Tuning of ENA ® Gapmers as Antisense Oligonucleotides for Sequence-Specific Inhibition

Miho Takagi-Sato, Shinya Tokuhiro, Reimi Kawaida [...]

Nucleic Acid Therapeutics

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Research article

First published 2022-02

Evaluation of Phosphorus and Non-Phosphorus Neutral Oligonucleotide Backbones for Enhancing Therapeutic Index of Gapmer Antisense Oligonucleotides

Guillermo Vasquez, Michael T. Migawa, W. Brad Wan [...]

Nucleic Acid Therapeutics

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Research article

First published 2022-06

Allele-Selective LNA Gapmers for the Treatment of Fibrodysplasia Ossificans Progressiva Knock Down the Pathogenic ACVR1 R206H Transcript and Inhibit Osteogenic Differentiation

Rika Maruyama, Quynh Nguyen, Rohini Roy Roshmi [...]

Nucleic Acid Therapeutics

Open access

Research article

First published 2020-08

Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy

Andrew T. Watt, Grant Swayze, Eric E. Swayze [...]

Nucleic Acid Therapeutics

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Research article

First published 2019-08

Knockdown of Long Noncoding RNA Plasmacytoma Variant Translocation 1 with Antisense Locked Nucleic Acid GapmeRs Exerts Tumor-Suppressive Functions in Human Acute Erythroleukemia Cells Through Downregulation of C-MYC Expression

Mahsa Salehi, Mohammadreza Sharifi, Marzieh Bagheri

Cancer Biotherapy and Radiopharmaceuticals

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Research article

First published 2023-12

Highly Potent Antisense Oligonucleotides Locked Nucleic Acid Gapmers Targeting the SARS-CoV-2 RNA Genome

Vita Dauksaite, Ali Tas, Falk Wachowius [...]

Nucleic Acid Therapeutics

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