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Research article

First published 2019

Efficient Design of Integrated and Adaptively Interlinked Protocols for Early-Phase Drug Development Programs

Simon Coates, Oliver Pohl, Jean-Pierre Gotteland [...]

Therapeutic Innovation & Regulatory Science

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Other

First published 2003-09

ID2: A New Tool to Foster Innovation During the Early Phases of Design Projects

J. Legardeur, J. F. Boujut, H. Tiger

Concurrent Engineering

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Research article

First published 2013-6

Early phase trial design for assessing several dose levels for toxicity and efficacy for targeted agents

Antje Hoering, Alan Mitchell, Michael LeBlanc [...]

Clinical Trials

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Research article

First published 1989-10

Challenges in the Design of Phase I and Early Phase II Studies

George S. Hughes

Therapeutic Innovation & Regulatory Science

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Other

First published 2008-12

Adaptive designs for dose-finding in non-cancer phase II trials: influence of early unexpected outcomes

Matthieu Resche-Rigon, Sarah Zohar, Sylvie Chevret

Clinical Trials

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Research article

First published 2010-3

Design Support System by Combination of 3D-CAD and CAE with Preference Set-based Design Method

Masato Inoue, Yoon-Eui Nahm, Soshi Okawa [...]

Concurrent Engineering

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Research article

First published 2014-1

Adaptive Clinical Trials

Olga Marchenko, Valerii Fedorov, J. Jack Lee [...]

Therapeutic Innovation & Regulatory Science

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Other

First published 2002-10

Dose Spacing in Early Dose Response Clinical Trial Designs

Anthony Hamlett, Naitee Ting, R. Choudary Hanumara [...]

Therapeutic Innovation & Regulatory Science

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Research article

First published 1991-7

Using Early Drug Development Data to Design Phase III Trials

James F. Ward, Ronald V. Nardi

Therapeutic Innovation & Regulatory Science

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Research article

First published 2019-10

Early phase modeling of frontal impacts for crashworthiness: From lumped mass–spring models to Deformation Space Models

Volker A Lange, Johannes Fender, Lailong Song [...]

Proceedings of the Institution of Mechanical Engineers,Part D: Journal of Automobile Engineering

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