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Retricted access

Review article

First published 2024-10-18

BACE1 Inhibitors for Alzheimer’s Disease: Current Challenges and Future Perspectives

Judite R.M. Coimbra, Rosa Resende, José B.A. Custódio [...]

Journal of Alzheimer’s Disease

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Research article

First published

sAβPP α is a Potent Endogenous Inhibitor of BACE1

Clare Peters-Libeu, Jesus Campagna, Michael Mitsumori [...]

Journal of Alzheimer’s Disease

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Review article

First published 2024-05-14

A Strategy for Allowing Earlier Diagnosis and Rigorous Evaluation of BACE1 Inhibitors in Preclinical Alzheimer’s Disease

Masuo Ohno

Journal of Alzheimer’s Disease

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Research article

First published 2020-08-18

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AβPP-β Cleavage Decreasing Amyloid-β Production and Accumulation in Alzheimer’s Disease Models

Rosa Resende, Marisa Ferreira-Marques, Patrícia Moreira [...]

Journal of Alzheimer’s Disease

Open access

Research article

First published 2022-01-11

Robust Pharmacodynamic Effect of LY3202626,a Central Nervous System Penetrant,Low Dose BACE1 Inhibitor,in Humans and Nonclinical Species

Brian A. Willis, Stephen L. Lowe, Scott A. Monk [...]

Journal of Alzheimer's Disease Reports

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Research article

First published 2005-06

A Continuous Time-Resolved Fluorescence Assay for Identification of BACE1 Inhibitors

Valentina Porcari, Letizia Magnoni, Georg C. Terstappen [...]

ASSAY and Drug Development Technologies

Open access

Research article

First published 2017-2-20

BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer’s Disease Markers in Elderly Healthy Participants

Maarten Timmers, Soraia Barão, Bianca Van Broeck [...]

Journal of Alzheimer’s Disease

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Research article

First published 2013-10-10

The Selective BACE1 Inhibitor VIa Reduces Amyloid-β Production in Cell and Mouse Models of Alzheimer's Disease

Xiaorui Cheng, Yu Zhou, Wei Gu [...]

Journal of Alzheimer’s Disease

Open access

Research article

First published 2016-2-22

AZD3293: A Novel,Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

Susanna Eketjäll, Juliette Janson, Karin Kaspersson [...]

Journal of Alzheimer’s Disease

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Research article

First published 2014-7-25

Design of Multi-Target Compounds as AChE,BACE1,and Amyloid-β 1-42 Oligomerization Inhibitors: In Silico and In Vitro Studies

Maricarmen Hernández-Rodríguez, José Correa-Basurto, Federico Martínez-Ramos [...]

Journal of Alzheimer’s Disease

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