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Research article

First published 2015-10

The effect of heterogeneous variance on efficiency and power of cluster randomized trials with a balanced 2 × 2 factorial design

Francesca Lemme, Gerard JP van Breukelen, Math JJM Candel [...]

Statistical Methods in Medical Research

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Other

First published 2010-7

Design Archetypes for Phase 2 Clinical Trials in Central Nervous System Disorders

Craig H. Mallinckrodt, Michael J. Detke, William R. Prucka [...]

Therapeutic Innovation & Regulatory Science

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Research article

First published 2012-7

Designing Phase 2 Trials Based on Program-Level Considerations

Nitin Patel, James Bolognese, Christy Chuang-Stein [...]

Therapeutic Innovation & Regulatory Science

Open access

Research article

First published 2020-10

Clinical trial design in phase 2 and 3 trials for pulmonary hypertension

Sylvia Nikkho, Peter Fernandes, R. James White

Pulmonary Circulation

Open access

Review article

First published 2024-12

Selecting Informative Patients for Phase 2 Progressive Trials in MS: Design Considerations for Phase 2 Clinical Trials in Progressive MS

Marcus W. Koch, Carlos Camara-Lemarroy, Eva Strijbis [...]

Multiple Sclerosis Journal

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Research article

First published 2017-1

Methodological Extensions of Phase 2 Trial Designs Based on Program-Level Considerations

James Bolognese, Jaydeep Bhattacharyya, Chris Assaid [...]

Therapeutic Innovation & Regulatory Science

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Research article

First published 2014-6

Considerations in the design of randomized trials to screen for type 2 diabetes

Justin B Echouffo-Tcheugui, Philip C Prorok

Clinical Trials

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Research article

First published 2020-2

Recommendations for improving clinical trial design to facilitate the study of youth-onset type 2 diabetes

Muhammad Yazid Jalaludin, Margarita Barrientos-Pérez, Mona Hafez [...]

Clinical Trials

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Other

First published 2005-4

A New Clinical Trial Design Combining Phases 2 and 3: Sequential Designs with Treatment Selection and a Change of Endpoint

Susan Todd, Nigel Stallard

Therapeutic Innovation & Regulatory Science

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Research article

First published 2025-8

Comparison of adaptive seamless Phase 2/3 designs for dose selection in clinical trials with multiple endpoints

Man Jin

Clinical Trials

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